ChiroACCESS Clinical Review

Attention Deficit Hyperactivity Disorder: Prevention

This information is provided to you for use in conjunction with your clinical judgment and the specific needs of the patient.

Lead Author(s): 

Dwain M. Daniel, D.C.


How this evidence was rated:

Strength of Recommendation Taxonomy (SORT)

Published on

October 1, 2009

Text Size:     
Risk factors for attention deficit-hyperactivity disorder (ADHD) are difficult to firmly establish due to the uncertain nature of the condition. A great deal of controversy exists related to its biological cause and diagnosis (1). Without the knowledge of its etiology or objective tests for diagnosis, it is difficult to properly design a study to determine risk factors. Consequently all evidence relating to risk factors are primarily observational in nature and must be evaluated on that basis.

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Furman LM. Attention-deficit hyperactivity disorder (ADHD): does new research support old concepts? J Child Neurol 2008 Jul;23(7):775-84.


Cormier E. Attention deficit/hyperactivity disorder: a review and update. J Pediatr Nurs 2008 Oct;23(5):345-57.


Furman L. What is attention-deficit hyperactivity disorder (ADHD)? J Child Neurol 2005 Dec;20(12):994-1002.


Zimmerman FJ, Christakis DA. Associations between content types of early media exposure and subsequent attentional problems. Pediatrics 2007 Nov;120(5):986-92.


St Sauver JL, Barbaresi WJ, Katusic SK, Colligan RC, Weaver AL, Jacobsen SJ. Early life risk factors for attention-deficit/hyperactivity disorder: a population-based cohort study. Mayo Clin Proc 2004 Sep;79(9):1124-31.


Connor DF, Edwards G, Fletcher KE, Baird J, Barkley RA, Steingard RJ. Correlates of comorbid psychopathology in children with ADHD. J Am Acad Child Adolesc Psychiatry 2003 Feb;42(2):193-200.


Van den Bergh BR, Marcoen A. High antenatal maternal anxiety is related to ADHD symptoms, externalizing problems, and anxiety in 8- and 9-year-olds. Child Dev 2004 Jul;75(4):1085-97.


Braun JM, Kahn RS, Froehlich T, Auinger P, Lanphear BP. Exposures to environmental toxicants and attention deficit hyperactivity disorder in U.S. children. Environ Health Perspect 2006 Dec;114(12):1904-9.


Day NL, Richardson GA, Goldschmidt L, Cornelius MD. Effects of prenatal tobacco exposure on preschoolers' behavior. J Dev Behav Pediatr 2000 Jun;21(3):180-8.


Fergusson DM, Horwood LJ, Lynskey MT. Early dentine lead levels and subsequent cognitive and behavioural development. J Child Psychol Psychiatry 1993 Feb;34(2):215-27.


Huizink AC, Mulder EJ. Maternal smoking, drinking or cannabis use during pregnancy and neurobehavioral and cognitive functioning in human offspring. Neurosci Biobehav Rev 2006;30(1):24-41.


Williams JH, Ross L. Consequences of prenatal toxin exposure for mental health in children and adolescents: a systematic review. Eur Child Adolesc Psychiatry 2007 Jun;16(4):243-53.


Linnet KM, Dalsgaard S, Obel C, Wisborg K, Henriksen TB, Rodriguez A, et al. Maternal lifestyle factors in pregnancy risk of attention deficit hyperactivity disorder and associated behaviors: review of the current evidence. Am J Psychiatry 2003 Jun;160(6):1028-40.


Nigg JT, Knottnerus GM, Martel MM, Nikolas M, Cavanagh K, Karmaus W, et al. Low Blood Lead Levels Associated with Clinically Diagnosed Attention-Deficit/Hyperactivity Disorder and Mediated by Weak Cognitive Control. Biological Psychiatry 2008 Feb 1;63(3):325-31.


Thomson GO, Raab GM, Hepburn WS, Hunter R, Fulton M, Laxen DP. Blood-lead levels and children's behaviour--results from the Edinburgh Lead Study. J Child Psychol Psychiatry 1989 Jul;30(4):515-28.


Ha M, Kwon HJ, Lim MH, Jee YK, Hong YC, Leem JH, et al. Low blood levels of lead and mercury and symptoms of attention deficit hyperactivity in children: a report of the children's health and environment research (CHEER). Neurotoxicology 2009 Jan;30(1):31-6.


Cheuk DK, Wong V. Attention-deficit hyperactivity disorder and blood mercury level: a case-control study in chinese children. Neuropediatrics 2006 Aug;37(4):234-40.


Lee DH, Jacobs DR, Porta M. Association of serum concentrations of persistent organic pollutants with the prevalence of learning disability and attention deficit disorder. J Epidemiol Community Health 2007 Jul;61(7):591-6.


Bouchard M, Laforest F, Vandelac L, Bellinger D, Mergler D. Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water. Environ Health Perspect 2007 Jan;115(1):122-7.


Jacobson JL, Jacobson SW. Prenatal exposure to polychlorinated biphenyls and attention at school age. J Pediatr 2003 Dec;143(6):780-8.


Joshi K, Lad S, Kale M, Patwardhan B, Mahadik SP, Patni B, et al. Supplementation with flax oil and vitamin C improves the outcome of Attention Deficit Hyperactivity Disorder (ADHD). Prostaglandins Leukot Essent Fatty Acids 2006 Jan;74(1):17-21.


Antalis CJ, Stevens LJ, Campbell M, Pazdro R, Ericson K, Burgess JR. Omega-3 fatty acid status in attention-deficit/hyperactivity disorder. Prostaglandins Leukot Essent Fatty Acids 2006 Oct;75(4-5):299-308.


Stevens L, Zhang W, Peck L, Kuczek T, Grevstad N, Mahon A, et al. EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors. Lipids 2003 Oct;38(10):1007-21.


McCann JC, Ames BN. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 2008 Apr;22(4):982-1001.


Konofal E, Lecendreux M, Deron J, Marchand M, Cortese S, Zaim M, et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol 2008 Jan;38(1):20-6.


Curtis LT, Patel K. Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder (ADHD): a review. J Altern Complement Med 2008 Jan;14(1):79-85.


Rojas NL, Chan E. Old and new controversies in the alternative treatment of attention-deficit hyperactivity disorder. Ment Retard Dev Disabil Res Rev 2005;11(2):116-30.


Bateman B, Warner JO, Hutchinson E, Dean T, Rowlandson P, Gant C, et al. The effects of a double blind, placebo controlled, artificial food colourings and benzoate preservative challenge on hyperactivity in a general population sample of preschool children. Arch Dis Child 2004 Jun;89(6):506-11.


Schab DW, Trinh NH. Do artificial food colors promote hyperactivity in children with hyperactive syndromes? A meta-analysis of double-blind placebo-controlled trials. J Dev Behav Pediatr 2004 Dec;25(6):423-34.


Boris M, Mandel FS. Foods and additives are common causes of the attention deficit hyperactive disorder in children. Ann Allergy 1994 May;72(5):462-8.


Wigal SB, Wigal TL. Special considerations in diagnosing and treating attention-deficit/hyperactivity disorder. CNS Spectr 2007 Jun;12(6 Suppl 9):1-14.


Kanarek RB. Does sucrose or aspartame cause hyperactivity in children? Nutr Rev 1994 May;52(5):173-5.


van der MJ, Borger NA, Potgieter ST, Pirila S, De CP. Very Low Birth Weight and Attention Deficit/Hyperactivity Disorder. Child Neuropsychol 2009 Jun 18;1-14.


Hayes B, Sharif F. Behavioural and emotional outcome of very low birth weight infants - literature review. J Matern Fetal Neonatal Med 2009 Jun 10;1-8.


Millichap JG. Etiologic classification of attention-deficit/hyperactivity disorder. Pediatrics 2008 Feb;121(2):e358-e365.


Geirsson RT. Birth trauma and brain damage. Baillieres Clin Obstet Gynaecol 1988 Mar;2(1):195-212.


McKinlay A, Grace RC, Horwood LJ, Fergusson DM, Macfarlane MR. Long-term behavioural outcomes of pre-school mild traumatic brain injury. Child Care Health Dev 2009 Feb 12.


Heron J, Golding J. Thimerosal exposure in infants and developmental disorders: a prospective cohort study in the United kingdom does not support a causal association. Pediatrics 2004 Sep;114(3):577-83.